04-16-2024, 06:12 AM
Fildena 25 contains sildenafil citrate as its active ingredient. Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor, which works by blocking the action of the enzyme PDE5 in the smooth muscle cells of the penis.
Here's how sildenafil works to treat erectile dysfunction (ED):
Relaxation of Blood Vessels: When a man is sexually aroused, nitric oxide (NO) is released in the erectile tissue of the penis. NO activates an enzyme called guanylate cyclase, which leads to increased levels of cyclic guanosine monophosphate (cGMP).
Increased cGMP Levels: cGMP is a signaling molecule that relaxes the smooth muscles in the blood vessels of the penis, allowing them to dilate and increase blood flow. This increased blood flow leads to an erection.
PDE5 Inhibition: However, the enzyme PDE5 can degrade cGMP, reducing its levels and causing the smooth muscles to contract, which can result in difficulty achieving or maintaining an erection. Sildenafil in Fildena 25 mg inhibits PDE5, preventing it from breaking down cGMP and helping to maintain higher levels of cGMP in the penis.
[b]Improved Erection:[/b] By blocking PDE5 and increasing cGMP levels, sildenafil promotes relaxation of the smooth muscles and enhanced blood flow to the penis, resulting in improved erectile function and the ability to achieve and sustain an erection sufficient for sexual activity.